Glutathione is a tripeptide compound formed by the condensation of glutamic acid, cysteine and glycine through peptide bonds. It is the most important low-molecular-weight thiol in mammalian cells against oxidative stress. It was discovered in 1921 and the chemical structure was determined in 1930. Dr. Al Mindell, a famous American nutrition and health care expert, called glutathione an anti-aging amino acid with three times the potency, also known as nature's anti-oxidant master. Colorless transparent slender granular crystal, soluble in water, dilute alcohol, liquid ammonia, dimethylformamide, insoluble in ethanol, ether, acetone. When it is solid, its properties are stable, and its aqueous solution is easily oxidized to oxidized glutathione in the air, which is widely found in baker's yeast, wheat germ, animal liver, chicken blood, pig blood, tomatoes, pineapples, and cucumbers, among which wheat The highest in germ and animal liver, the content is as high as 100 ~ 1000mg/100g. It has the functions of anti-oxidation, scavenging free radicals, detoxification, enhancing immunity, anti-aging, anti-cancer, and anti-radiation hazard. Also Chemicalbook helps white blood cells kill bacteria, prevent oxidation of vitamins C and E, and prevent stroke and cataract formation. In addition, glutathione also binds carcinogens and excretes them through urine. The liver is the most important detoxification organ in the human body, and the rich glutathione (GSH) contained in it plays a protective role in the synthesis, detoxification, and estrogen inactivation of the liver. It is the body's primary antioxidant to counteract the damage of free radicals, which are contributing factors to aging and disease. When the liver is damaged, such as suffering from various liver diseases, the human body will consume a large amount of GSH to help the injured liver to repair and detoxify itself, resulting in a significant decrease in glutathione in the body. At this time, we need to take some glutathione drugs to help the injured liver repair itself. Therefore, glutathione drugs are suitable for viral hepatitis (such as hepatitis A, hepatitis B, etc.), alcoholic liver disease, drug-induced liver disease, fatty liver and other liver diseases, and are good liver protection medicines for patients with liver diseases.
The molecular weight of glutathione is 307.33, the melting point is 189～193℃ (decomposition), the crystal is colorless and transparent elongated column, and the isoelectric point is 5.93. It is soluble in water, dilute alcohol, liquid ammonia and methylformamide, but insoluble in alcohol, ether and acetone. In vivo, only GSH has physiological activity, and GSSG needs to be reduced before it can play its important physiological functions. GSH is not easy to be stored under high water activity, and long-term stable storage can only be achieved if the water activity is controlled below 0.3. Studies have shown that in the vitamin C aqueous solution containing GSH (pH 3.3), due to the strong reducing effect of vitamin C, the GSH in the solution will not be oxidized to GSSG, but its decomposition rate is accelerated; The GSSG in the product will not be converted into GSChemicalbookH, and the storage stability is very good. And orally ingested GSSG can be reduced to GSH in the upper part of the small intestine, and absorbed by γ-GTP (decomposing GSH into glutamate and Cys-Gly) and dipeptidase on the surface of small intestinal epithelial cells. perform its important physiological functions. Glutathione is widely found in animals and plants, and its content is extremely high in baker's yeast, wheat germ and animal liver, reaching 100-1000mg/100g; it is also abundant in human and animal blood, such as human blood. It contains 26-34mg/100g, chicken blood contains 58-73mg/100g, pig blood contains 10-15mg/100g, and dog blood contains 14-22mg/100g. GSH is also found in many vegetables, potatoes and grains
1. Adding it to the flour products can play a reducing role. It not only shortens the time of making bread to one-half or one-third of the original, but also greatly improves labor conditions, and plays a role in strengthening food nutrition and other functions.
2. Adding Chemicalbook to yogurt and baby food is equivalent to vitamin C, which can act as a stabilizer.
3. Mix it into the fish cake to prevent the color from deepening.
4. When added to meat products and cheeses, it has the effect of enhancing the flavor.
Reduced glutathione (GSH) is an important substance in cells. It is composed of glutamic acid, cysteine and glycine, and contains sulfhydryl groups. It plays an important role in maintaining the biological function of cells and has a variety of biochemical functions, including participation in The tricarboxylic acid cycle and sugar metabolism are coenzymes of glyceraldehyde phosphate dehydrogenase and triose phosphate dehydrogenase, which can activate various enzymes, promote the metabolism of sugar, fat and protein, and affect the metabolic process of cells; The combination of free radicals and electrophilic groups is converted into easily metabolized acid substances, which accelerates the excretion of free radicals, protects cells from damage, reduces the toxic effects of chemotherapy and radiotherapy, and protects renal tubules from cisplatin damage. GSH can be combined with pro-Chemicalbook hepatotoxic substances to protect the synthesis, detoxification, inactivation of hormones and other functions of the liver, promote bile acid metabolism, and facilitate the absorption of fat and fat-soluble vitamins in the digestive tract. It is suitable for alleviating the toxic effects of chemotherapy and radiotherapy, especially high-dose chemotherapy; or for the treatment of various hypoxemias, such as acute anemia, acute respiratory distress syndrome, sepsis, etc.; it can be used for liver diseases, including viral, Treatment of liver damage caused by drug, alcohol and other chemical toxicity. In addition, reduced glutathione can also be used for adjuvant treatment of organophosphorus, amino or nitroaromatic compound poisoning. It also has a therapeutic effect on acute drug-induced kidney injury, uremia, diabetic complications and neuropathy.
Glutathione has a broad-spectrum detoxification effect, and can combine with toxic compounds such as acrylonitrile, fluoride, carbon monoxide, heavy metal ions or carcinogens that enter the body, and promote its excretion from the body. It can be used for the treatment of poisoning caused by the above substances .
It has anti-allergic effect and can treat allergies caused by the imbalance of acetylcholine and cholinesterase in the human body.
It has the effect of protecting the liver and inhibiting the formation of fatty liver. It can not only be used as a liver-protecting agent, but also can be used as a feed additive, and has a liver-protecting effect on fish and cattle. In breeding, due to over-stocking and unclean feed, fish and dairy cattle often come out of the Liver dysfunction is present, and adding glutathione can improve liver function.
Many biochemical reactions in the human body are catalyzed by enzymes. Most of these enzymes use sulfhydryl groups as active groups. The state of sulfhydryl groups determines the activation and inhibition of enzyme activity. Glutathione is the natural activator of these enzymes in cells, and the sulfhydryl group contained in it can reduce the H2O2 generated by the metabolism of human cells to H2O, and remove free radicals in the human body. Free radicals can damage cell membranes, promote body aging, and induce tumors or arteriosclerosis. It has anti-peroxidation effect on human cells, and can also improve the antioxidant capacity of the skin, making the skin shiny. Human Chemicalbook aging, infection, poisoning, exogenous toxins, oxidative stress, and attack by electrophilic compounds can all reduce the level of GSH in the cytoplasm. Its degradation process is observed, so detecting the level of glutathione can early judge and detect apoptosis. Glutathione has the function of eliminating the generation of oxidized lipids, and has anti-oxidative effects on lipids. It can also prevent the presence of flavor-presenting nucleotides (inosinic acid, guanylic acid) in foods (fish cakes, sausages, soy sauce, etc.). Flavor nucleotides decompose and lose the umami flavor.
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